15
May
Betamethasone In Preterm Labor. Two smaller randomized trials have specifically assessed the use of betamethasone in the late preterm period to prevent adverse neonatal respiratory outcomes. It stimulates the synthesis and release of surfactant 2 which lubricates the lungs allowing the air sacs to slide against one another without sticking when the infant breathes. The most common steroid betamethasone celestone is given in two doses 12 milligrams mg each 12 or 24 hours apart. 17 18 however these studies were.
Betamethasone has a higher affinity for the glucocorticoid receptor and a longer plasma half life. Two smaller randomized trials have specifically assessed the use of betamethasone in the late preterm period to prevent adverse neonatal respiratory outcomes. Because of the nature of preterm labour and the difficulty in predicting timing to delivery optimum efficacy is paramount. Antenatal betamethasone is primarily used to speed up lung development in preterm fetuses. Women at risk for preterm delivery who were between gestational age of 23 weeks and 34 weeks were randomized to receive the standard two doses of betamethasone either 12 hours n 140 or 24 hours n 70 apart. The beneficial effects of betamethasone are therefore probably greater.
The most common steroid betamethasone celestone is given in two doses 12 milligrams mg each 12 or 24 hours apart.
Betamethasone has a higher affinity for the glucocorticoid receptor and a longer plasma half life. Women at risk for preterm delivery who were between gestational age of 23 weeks and 34 weeks were randomized to receive the standard two doses of betamethasone either 12 hours n 140 or 24 hours n 70 apart. A beneficial effects on fetal maturation are greatest 24 hours after initiating therapy and extend up to at least 7 days. Betamethasone causes the release of surfactant a substance that lubricates the lungs so that they do not stick together when the infant breathes. Betamethasone has a higher affinity for the glucocorticoid receptor and a longer plasma half life. Two smaller randomized trials have specifically assessed the use of betamethasone in the late preterm period to prevent adverse neonatal respiratory outcomes.