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Antineoplastic Drugs Classification. Most antineoplastic agents are classified according to their structure or cell cycle activity either cell cycle phase specific or cell cycle phase non specific 9. Non antineoplastic drugs that meet one or more of the niosh criteria for a haz ardous drug. Please refer to the drug classes listed below for further information. Antineoplastic agents inn route mechanism of action indications major toxicities.
Please refer to the drug classes listed below for further information. Dna methyltransferase inhibitor and incorporates itself into rna hence inhibiting gene expression. Cell cycle phase specific agents act on the cells in a specific phase. Note that many of these drugs may also pose a reproduc tive risk for susceptible populations table 1. Proach involves three groups of drugs. Type 2 agents were those preferentially toxic to cells under hypoxic conditions.
Most antineoplastic agents are classified according to their structure or cell cycle activity either cell cycle phase specific or cell cycle phase non specific 9.
An antineoplastic agent used in the treatment of her2 positive metastatic breast cancer in combination with other antineoplastic agents. These include mitomycin c and adriamycin. This group includes bleomycin procarbazine strepto nigrin actinomycin d and vincristine. Antineoplastic agents inn route mechanism of action indications major toxicities. Several antineoplastic agents showed no major preferential toxicity to cells under the conditions of oxygenation or hypoxia used in these experiments and were placed in a third class. This group type 3 includes 1 3 bis 2 chloroethyl 1 nitrosourea 1 2 chloroethyl 3 cyclohexyl 1 nitrosourea cis diamminedichloroplatinum ii 5 fluorouracil.