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Antineoplastic Agents Classification. Note that many of these drugs may also pose a reproduc tive risk for susceptible populations table 1. Alkylating agents antimetabolites mitotic inhibitors antineoplastic antibiotics hormonal agents and miscellaneous. While their action is intended to target abnormal cells normal cells are also affected. Classification of antineoplastic agents i.
Cytotoxic drugs directly act on cells a alkylating agents i. Conventional cytotoxic antineoplastic agents can be grouped by biochemical mechanism of action into the following general categories. These drugs can work by affecting cell survival or by boosting the immune system in its efforts to combat the abnormal cells. A purine analog antimetabolite that inhibits dna synthesis. Cytotoxic drugs directly act on cells a alkylating agents i. Most antineoplastic agents are classified according to their structure or cell cycle activity either cell cycle phase specific or cell cycle phase non specific 9 cell cycle phase specific agents act on the cells in a specific phase.
Classification of antineoplastic agents i.
Most antineoplastic agents are classified according to their structure or cell cycle activity either cell cycle phase specific or cell cycle phase non specific 9 cell cycle phase specific agents act on the cells in a specific phase. Mechlorethamine cyclophosphamide melphalan chlorambucil ii. An antineoplastic agent used to treat acute lymphocytic leukemia. Conventional cytotoxic antineoplastic agents can be grouped by biochemical mechanism of action into the following general categories. Antineoplastic agents inn route mechanism of action indications major toxicities. Several antineoplastic agents showed no major preferential toxicity to cells under the conditions of oxygenation or hypoxia used in these experiments and were placed in a third class.